1. What is the MDRD Equation?

The MDRD (Modification of Diet in Renal Disease) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. It was developed to provide a more accurate assessment of kidney function than the Cockcroft-Gault formula.

2. How Does the Calculator Work?

The calculator uses the MDRD equation:

Where:

• \( Scr \) — Serum creatinine (mg/dL)
• \( Age \) — Age in years
• 0.742 — Female multiplier
• 1.212 — African American race multiplier

Explanation: The equation accounts for the inverse relationship between creatinine and GFR, with adjustments for age, gender, and race.

3. Importance of GFR Calculation

Details: GFR estimation is essential for diagnosing chronic kidney disease, determining disease stage, and guiding medication dosing decisions.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. All values must be valid (creatinine > 0, age between 1-120).

5. Frequently Asked Questions (FAQ)

Q1: Why use MDRD equation?
A: The MDRD equation is widely validated and provides a good estimate of GFR, especially for patients with chronic kidney disease.

Q2: What are normal GFR values?
A: Normal GFR is generally ≥90 mL/min/1.73m², though values decline with age. Below 60 for 3+ months indicates CKD.

Q3: When should creatinine be measured?
A: Morning fasting sample is ideal, but random samples are acceptable. Avoid testing after meat-heavy meals or vigorous exercise.

Q4: Are there limitations to this equation?
A: Less accurate in extremes of age/weight, amputees, pregnant women, and those with normal or near-normal kidney function.

Q5: Should this be used for drug dosing?
A: For precise drug dosing, measured GFR may be needed in certain populations, especially at higher GFR levels.